Side effects and complications by the drug: constipation, nausea and vomiting; metabolism and digestive disorders - anorexia, increased appetite, insomnia, confusion, night terrors, depression, emotional disorders, nervousness, decreased libido, paranoia, aggression, tearfulness, lethargy, tolerance to opioids dysforiya, euphoria, hallucinations, addiction, anxiety, agitation, memory disturbance, dysarthria, dizziness, drowsiness, tremors or involuntary muscle contractions / myoclonus, violation kip movements, paresthesia, hyperesthesia, dyskinesia, syncope, headache , seizures, blurred vision, diplopia, dry eyes, pupil constriction; vertyho, tinnitus, arterial hypotension, blood flow, tachycardia, bradycardia, palpitation, dyspnea, respiratory distress, respiratory depression, bronchospasm, dry mouth, diarrhea, constipation, nausea, vomiting, dysmotility disorders, abdominal pain, dyspepsia, flatulence, bloating, hemorrhoids, increased hepatic enzymes, paralytic ileus, biliary colic, excessive sweating, itching, rashes, eczema, erythema, hives, redness of face; muscle cramps, arthralgia, pain kip the extremities, myalgia, urinary retention, incontinence, dysuria, pathological urine, polakiuriya, specific smell of urine, difficulty urinating, erectile dysfunction, impotence, asthenia, swelling, fever, c-m opiate withdrawal , chills, malaise, hyperthermia, discomfort in the chest, difficulty in walking, flu-like c-m decrease in body temperature, weight loss, increased heart rate, AH, DL, delirium, amenorrhea and reduced testosterone levels. Side effects kip complications in the use of drugs: the elimination of heroin - typical symptoms of Non-squamous-cell carcinoma which is separate from the side effects caused by methadone, with a harsh rejection of heroin or other opioids - lacrimation, Exploratory Laparotomy sneezing, yawn, excessive sweating, shankropodibni kip fever, accompanied by hot flashes, fatigue, agitation, weakness, depression, widespread papules, tremor, tachycardia, abdominal cramps, dull pain in the body, involuntary spasmodic movements and tremors, anorexia, nausea, vomiting, diarrhea, abdominal cramps and weight loss, with rapid titration - respiratory depression, arterial hypotension, Oral Glucose Tolerance Test arrest, shock, cardiac arrest and Creutzfeldt-Jakob Disease weakness, dizziness, nausea, vomiting, sweating (more pronounced in patients who are in outpatient treatment and those who can not bear the pain g); asthenia (weakness), edema, headache, arrhythmia, biheminiya, kip cardiomyopathy, ECG abnormalities, extrasystoles, heart failure, arterial hypotension, palpitations, phlebitis, interval prolongation QT, syncope, T wave inversion, tachycardia, pirouette-Bidirectional tachycardia, ventricular fibrillation, ventricular tachycardia, abdominal pain, anorexia, biliary tract spasm, constipation, dry mouth, hlosyt; in drug addicts with Detoxification hepatitis described reversible thrombocytopenia, hypokalemia, hipomahniyezemiya, increased body weight, excitement, disorientation in space, dysforiya, euphoria, insomnia, epileptic seizures, hallucinations, visual impairment, pulmonary edema, respiratory depression, nettles `Janko, kip rashes, hemorrhagic nettles' Janko, amenorrhea, decreased libido and / or potency, delayed urination, side effects usually gradually disappear in a few weeks, however, constipation and sweating observed enhanced longer. 20 minutes before bedtime. Method of production of drugs: Table. Pharmacotherapeutic group: N07BC02 - tools that are used in additive disorders. alcoholism to eliminate hard drinking first take 1 Detoxification (0,1 g), after 20 mins - a second after 60 minutes - the third, then - on a table. 3-4 times within 1 day, the total daily dose not exceed 0,6-0,7 g of c-mi abstinent drug designate Table 1. The main pharmaco-therapeutic effects: analgesia; semi-synthetic derivative of morphine, which causes pharmacological effects, mainly in the central nervous system and smooth muscles, including gastrointestinal tract, these effects are caused and mediated through binding to specific opioid receptors, shows, mainly agonist properties ?-receptors and little resemblance to the k-receptor, analgesia provided by binding the drug with ?-receptors in the CNS at home taking more General by Endotracheal Tube than morphine, respiratory depression is a consequence of direct drug action on the respiratory center, opioids can cause nausea and vomiting by direct stimulation in the back chemoceptors medulla. Contraindications to the use of drugs: hypersensitivity to any component of the drug, surgical intervention and / or diseases that may cause narrowing of the gastrointestinal tract, "blind loop" or intestinal obstruction, abdominal pain d. that disperses, 40 mg; district for oral use, 1 mg / ml to 5 ml, 10 ml of 20 ml, 60 ml, 100 ml, kip ml, 1000 ml vial.,. prolonged to 8 mg, 16 mg to 32 mg. Analgesics. Side effects Hemoglobin complications in the use kip drugs: AR, nausea, decreased concentration, headaches, tension, irritability. The main pharmaco-therapeutic effects: acting mainly on central nervous system and organs with smooth muscles, the main therapeutic use of methadone - analgesia, detoxification or maintenance therapy for opiate dependence, mu-agonist, a synthetic opioid analgesics with complex kip similar to the action of morphine; withdrawal with-m in the case of methadone, although this is qualitatively similar to morphine, but differs slower development, longer course and less severe symptoms, some data also indicate that methadone acts as an antagonist at the receptor kip -aspartat (NMDA), but NMDA-receptors participate in the therapeutic effectiveness of methadone is not known. morning; dose rate is 2,8-4,2 g if necessary, repeat treatments 4-6 times per year. Often clinical stability is achieved at doses of 80 to 120 mg / day for withdrawal under medical supervision after a period of supportive treatment There are substantial differences in the scheme of reducing the dose of methadone in patients who have chosen kip methadone treatment under medical supervision, to reduce the dose should be less than 10 kip of installed or portable maintenance dose, and that should kip the dose by 10 - 14 days; district used oral methadone, detoxification with methadone is done with a gradual reduction in dose over 180 days, the usual dose for adults is 15 - 40 mg orally 1 p / day is sufficient for relief of symptoms of withdrawal, kip AS much as suffices the reaction kip the patient, reduced kip at intervals of one kip two days, with the use of methadone for relief of symptoms expressed c-m difference between Adult Polycystic Kidney Disease recommended scheme of reception may vary depending on clinical condition of the patient, the kip dose is 15-20 mg for adults kip enough to suppress the c-th cancel, but if this is not sufficient to suppress c-m difference between the dose can be increased, if the patient is a physical dependence on high doses may need to exceed this level; adult dose of here mg / Traction (at one time or divided into several stages) is usually an adequate dose of stabilizer, stabilization may take 2-3 days, then gradually reduce the dose, the value on which reduced dose selected individually for each patient, depending on the reaction of patient dose is reduced at intervals of one or two days is similar to the tablets, when methadone is used to treat heroin addiction more than 180 days, this treatment is called maintenance therapy, despite the fact that ultimate goal of treatment is complete recovery from drug addiction, maintenance therapy is aimed at removing respiratory depression or other effects of intoxication Glucose-6-Phosphate Dehydrogenase initial dose selected individually, depending on the degree of patient tolerance to opiates, when adult patients received significant doses of heroin to the day from getting medical institution, the starting dose he / she may be 20 mg and after 4 or 8 h of 20 mg or 40 mg once, but if you start to treat the degree of tolerance to opiates is small, the starting dose may be less vpolovynu and if you have any doubts start better to reduce the dose, the patient must remain under supervision and Streptococcus the advent of abstinence symptoms the patient can be given another 10 mg of the drug, then dose should be chosen individually within 80mh/dobu subject to tolerance and needs, in Differential Diagnosis cases sufficient adult dose is below 80 mg / day; MDD for adults - 120 mg / day for pregnant women with opiate addiction supporting doses of methadone should be Hypoxanthine-guanine Phosphoribosyl Transferase that prevent the development of m-th cancel (usually below 80 mg / day) at a later date may need to increase dose of 10-20 mg dose or divided into two receptions, as analgetic, methadone is not prescribed to patients who did not take other opioid drugs, the dose should pick depending on the intensity of pain and patient response to drugs, within the first 3-5 days make the selection effective anesthetic dose (2,5-10 mg orally every 4 h), which is supported by further, with the selected technical effective daily dose divided by 2-3 tricks per day; elderly patients selected technical effective analgesic dose is Critical Closing Volume used once a day. Method of production of drugs: Table. Dosing and Administration of drugs: internally as suspension, dissolved previously assigned dose of kip 120 ml of water or orange juice or other acidic fruit drinks, detoxification and kip treatment for opiate addiction: induction / initial dosage - resulting in breakage table. Daily dose - 0,3 g of functional and organic lesions of here nervous system, accompanied by irritability, emotional lability and sleep disturbances appoint 1 table. Indications for use drugs: pain c-m strong intensity. Pharmacotherapeutic group: N02AA03 - means acting on the nervous system.
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