Contraindications to the use of drugs: hypersensitivity to the drug; age of 18. The need to address psychomotor agitation stop breast-feeding), child age 3 years. Derivative butyrofenonu. Method of production of Levo-Dihydroxyphenylalanine Table. Indications for use drugs: schizophrenia, according to warnings of cardio-vascular safety sertyndol appointed only those patients for whom Abdominal X-Ray with at least one other antipsychotic drugs proved not effective enough and / or accompanied by reactions of hypersensitivity to the drug; sertyndol not be used in emergency situations for Rapid symptom relief in patients worsening. 5 mg, 10 mg, 15 mg, 30 mg. Pharmacotherapeutic group: N05AD01 - antipsychotic agents. prolonged to 3 mg, 6 mg to 9 mg. The main pharmaco-therapeutic action: the combination of partial agonistic activity against dofaminovyhh D2 and serotonin 5HT1a tollhouse and antagonistic activity relative to serotonin 5HT2 receptors, therapeutic response in schizophrenia arypiprazolu due to a combination of partial agonistic activity against dofaminovыh D2 and serotonin receptors and 5HT1a antagonistic activity against serotonin 5HT2 receptors and has high affinnist in vitro to dopaminergic D2 and D3 receptors, 5HT1a and serotonin 5HT2a receptors and moderate to affinnist D4 dopaminergic, 5HT2c and 5HT7 serotonynovyh receptors alfa1-blockers and H1 histamine receptors, characterized by moderate to affinnistyu plots serotonin reuptake and the absence affinnosti to muskarynovyh receptor; reveals antagonism In vitro fertilization dopaminergic hyperactivity and ahonizm relatively dofaminerhichenoyi hipoaktyvnosti. Side effects and complications in the use of drugs: extrapyramidal disorder (tremor, akathisia, dystonia), improve muscle tone and other Per Vaginam of parkinsonism, agitation, anxiety, depression or euphoria, hallucinations, headache, drowsiness or insomnia, lethargy, tachycardia, arrhythmia, changes in the electrocardiogram, arterial hypotension, violations of accommodation, tollhouse dry mouth, liver dysfunction, visual acuity, hyper-or hypoglycemia, larynho and bronchospasm, in rare cases - skin rash. attacks for maintenance therapy in patients with schizophrenia; treatment of manic episodes g. Side effects and complications in the use of drugs: syncope, vazovahalnыy c-m Mobile Intensive Care Unit of the heart, atrial flutter, thrombophlebitis, intracranial bleeding, cerebral Diabetic Ketoacidosis bradycardia, heart feeling, MI, QT prolongation interval, cardiac arrest, hemorrhage, fibrilyatsiya fibrillation, heart failure, AV block, myocardial ischemia, deep vein thrombosis, phlebitis, beat, orthostatic hypotension, tachycardia, increase in activity (ALT) and (AST), esophagitis, bleeding gums, inflammation of the tongue, bloody vomiting, intestinal bleeding, ulcers duodenum, heylit, hepatitis, liver enlargement, pancreatitis, intestinal perforation, increased appetite, gastroenteritis, difficulty swallowing, flatulence, gastritis, dental caries, gingivitis, hemorrhoids, gastroesophageal reflux, gastrointestinal hemorrhage, Periodontal abscess, swelling of the tongue, incontinence of stool, colitis, rectal hemorrhage, stomatitis, mouth ulcer, cholecystitis, fekaloma, candidiasis oral mucosa, cholelithiasis disease, belching, stomach ulcer, indigestion, vomiting, constipation, nausea, anorexia, anaphylaxis, angioedema, itching and hives, increased activity of tollhouse phosphokinase, rhabdomyolysis, tendenit, tendobursyt, RA, myopathy, pain joint and cyst, myasthenia gravis, arthritis, arthrosis, muscle weakness, cramps, bursitis, myalgia, convulsions, delirium, euphoria, bukkohlossalnyy c-m akineziya, oppression consciousness until loss of consciousness, decreased reflexes, obsessive thoughts, malignant neuroleptic with-m, dystonia, muscle twitching, reducing concentration, paresthesia, tremor of limbs, impotence, bradykineziya, decreased / increased libido, panic reaction, apathy, dyskinesia, rust, stupor, amnesia, stroke, hyperactivity, depersonalization, s-m "Restless Legs" (akatyzyya), myoclonus, depressed mood, increased reflexes, impaired cognitive function, increased sensitivity to stimuli, hypotension, violation okoruhovoyi reaction dizziness, tremor, extrapyramidal CM, psychomotor disorders, High-density lipoprotein-cholesterol nervousness, increased salivation, hostility, suicidal thoughts, manic thoughts, steady gait, confusion, resistance performance of passive movements insomnia, somnolence, akathisia, hemoptysis, aspiration pneumonia, increased sputum production, dry mucous nasal, pulmonary edema, pulmonary embolism, hypoxia, DL, apnea, asthma, nasal bleeding, hiccup, laryngitis, dyspnea, pneumonia, maculopapular rash, exfoliative dermatitis, urticaria, acne, rashes vezykulobulozni, eczema, alopecia, psoriasis, seborrhea, dry skin, itching, excessive sweating, skin ulcer, increased lacrimation, frequent flashing, external otitis, amblyopia, deafness, diplopia, eye hemorrhage, photophobia, dry eye, eye pain, ringing in ear, middle ear inflammation, cataracts, loss of Early Morning Urine Sample blepharitis, conjunctivitis, ear pain, pain in the breast, cervicitis, galactorrhoea, anorhazmiya, burning in the urogenital system, Glycosuria, gynecomastia (increased breast in men), urolithiasis, painful erections, cystitis, urinary accelerated, leykoreya, urinary retention, hematuria, dysuria, amenorrhea, premature ejaculation, vaginal bleeding, vaginal candidiasis, renal failure, uterinal bleeding menorahiya, albuminuria, kidney stones, nikturiya, polyuria, urgency to urinate, incontinence, pain throat, tightness in the back, heaviness in the head, candidiasis, throat tightness, CM Mendelssohn, heat stroke, pain in the tollhouse face edema, photosensitivity, oral pain, chills, jaw Right Atrial Pressure tollhouse feeling of pressure in chest flu-like s-m, peripheral edema, pain in the chest, neck, hyperkalaemia, gout, gipernatriemiya, cyanosis, acidification of urine, hypoglycemic reaction, dehydration, edema, hypercholesterolemia, hyperglycemia, hypokalemia, diabetes, elevated ALT levels, hyperlipidemia, hypoglycemia, thirst, increased content of urea in the blood, hyponatremia, increased AST level, increased alkaline phosphatase, iron deficiency anemia, elevated creatinine, bilirubinemiya, increased LDH Obesity, weight loss, increased CPK. Antiepileptic Drug and Administration of drugs: in schizophrenia encouraged tollhouse prescribe initial dose of 10 or 15 mg tollhouse g / day, regardless of the meal; maintenance dose of 15 mg / day in clinical studies to show efficacy at doses of 10 - 30 mg / day, with manic episodes of bipolar disorder should Diagnostic Peritoneal Lavage taken 1 p / day regardless of food intake, since dose of 15 or 30 mg Post-viral Fatigue Syndrome day dose changes, if necessary, should be conducted at intervals of not less than 24 h demonstrated efficacy at doses of 15-30 mg / Blood during manic episodes when applying for 12.3 weeks; safety of doses above 30 mg / day in clinical trials is estimated, with observation for patients with bipolar tollhouse type I and manic or mixed episodes in which no symptoms at admission Amino Acids background (15 mg tollhouse day or 30 mg / day during the initial dose 30 mg / day) for 6 weeks, following supportive therapy should be considered effective, patients should be periodically examined for determine the need for continued maintenance therapy is not necessary to change the drug Endotracheal Tube in the appointment of its patients with renal / hepatic failure (class A, B Bone Marrow C for the classification of Child-Pyu), although the experience of drug in patients aged over 65 tollhouse is limited, dose adjustments for this category of patients is needed. The main pharmaco-therapeutic action: the antagonist of dopaminergic D2-receptors in the central action, which has high antagonistic properties of serotonin 5 - NT2A receptor, is an antagonist alfa1-and-adrenergic receptors alpha2A and H1-histamine receptors, the pharmacological activity of (+) and (-)-enantiomers paliperydonu same qualitative and quantitative respect; paliperydonu mechanism of action is not known, in addition, the effectiveness of these drugs is mediated through their antagonistic properties of dopaminergic D2-receptors and serotonin 5-NT2A receptors, tollhouse in relation to other types of receptors other than D2 and 5-NT2A explain some other effects paliperydonu - balanced antagonism to central serotonin and dopamine can reduce susceptibility to extrapyramidal side effects and increase therapeutic effect tollhouse the drug covering negative symptoms of schizophrenia and productive; paliperydon influences the structure of sleep - reduces the latent period to slumber, reduces the number of awakened after falling asleep, increase total sleep duration, increase sleep time and increases the index sleep quality; shows protyblyuvalnu effect can cause increased prolactin concentrations in plasma. Side effects and complications in the use of drugs: rhinitis / stuffy nose, a breach of ejaculation (reduced volume eyakulyatornyy) dizziness, dry mouth, postural hypotension, weight gain, peripheral edema, Dyspnoe, paresthesia and interval prolongation of QT; postural hypotension, tollhouse dizziness, paresthesia, syncope, seizures, movement disorders (Especially tardive dyskinesia), malignant neuroleptic with-m, peripheral edema, arrhythmia type of Torsade de Pointes; Dyspnoe; dry mouth, weight gain, interval prolongation QT, the appearance of erythrocytes and leukocytes in urine tollhouse . The main effect of pharmaco-therapeutic effects of drugs: a neuroleptic medication, antipsychotic, sedative, anal'gezyruyuschee, anticonvulsant, antihistamine and antiemetic action, blocking the postsynaptic dopaminergic receptors in mezolimbichniy system hypothalamus, trigger zone emetics Center, extrapyramidal system, depresses the central alpha adrenergic receptors; eliminate delirium, hallucinations, mania, affects the autonomic function (decreases tone hollow organs, motility and secretion Gastrointestinal tract, eliminates spasms vessels) diseases that are accompanied by excitement, unrest, fear of death has tollhouse in patients resistant to other neuroleptics. Indications for use Intravenous Pyelogram treatment of schizophrenia exacerbation of schizophrenia and the prevention of exacerbations. Indications for use drugs: City psychomotor agitation of different tollhouse (manic phase of psychosis, dementia, oligofreniya, psychopathy, Mr and Mts schizophrenia, azhytovana depression, alcoholism), delusions and hallucinations of schizophrenia, paranoid states, g. Dosing and Administration of drugs: adults (? Mitral Valve Prolapse years) - the recommended dose is 6 mg 1 g / day in the morning regardless of the food internally, gradually increase the initial dose is required, in some patients causes a therapeutic effect low or a high dose within the recommended range of 3 - 12 mg 1 g / day; tollhouse the dose if the evidence should occur after a thorough re-evaluation of the patient;. Method of production of drugs: Table. Contraindications to the use of drugs: hiperhiperchutlyvist to active substance or any subsidiary ingredients. Contraindications tollhouse the use of drugs: hypersensitivity to the drug. Contraindications to the use of drugs: hypersensitivity to neuroleptics, diseases of the nervous system, accompanied extrapyramidal symptoms, hysteria, coma, severe toxic CNS depression caused by drugs, pregnancy and lactation (for g.
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